Ontology highlight
ABSTRACT:
SUBMITTER: Amacher JF
PROVIDER: S-EPMC3947174 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Amacher Jeanine F JF Cushing Patrick R PR Brooks Lionel L Boisguerin Prisca P Madden Dean R DR
Structure (London, England : 1993) 20131107 1
PDZ domain interactions are involved in signaling and trafficking pathways that coordinate crucial cellular processes. Alignment-based PDZ binding motifs identify the few most favorable residues at certain positions along the peptide backbone. However, sequences that bind the CAL (CFTR-associated ligand) PDZ domain reveal only a degenerate motif that overpredicts the true number of high-affinity interactors. Here, we combine extended peptide-array motif analysis with biochemical techniques to sh ...[more]