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Liraglutide decreases carotid intima-media thickness in patients with type 2 diabetes: 8-month prospective pilot study.


ABSTRACT: Liraglutide, a long-acting glucagon-like peptide-1 (GLP-1) analog, has several non- glycemic properties, but its effect on carotid intima-media thickness (IMT), a recognized marker of subclinical atherosclerosis, is still unknown.A prospective study of 8 months duration in 64 patients with type-2 diabetes and no prior history of coronary artery disease evaluated whether adding liraglutide to metformin affects carotid IMT, measured by color doppler ultrasound.After 8 months, fasting glucose decreased by 2.1 mmol/l and HbA1c by 1.9% (p?

SUBMITTER: Rizzo M 

PROVIDER: S-EPMC3948058 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Liraglutide decreases carotid intima-media thickness in patients with type 2 diabetes: 8-month prospective pilot study.

Rizzo Manfredi M   Chandalia Manisha M   Patti Angelo Maria AM   Di Bartolo Vittoria V   Rizvi Ali A AA   Montalto Giuseppe G   Abate Nicola N  

Cardiovascular diabetology 20140222


<h4>Background</h4>Liraglutide, a long-acting glucagon-like peptide-1 (GLP-1) analog, has several non- glycemic properties, but its effect on carotid intima-media thickness (IMT), a recognized marker of subclinical atherosclerosis, is still unknown.<h4>Methods</h4>A prospective study of 8 months duration in 64 patients with type-2 diabetes and no prior history of coronary artery disease evaluated whether adding liraglutide to metformin affects carotid IMT, measured by color doppler ultrasound.<h  ...[more]

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