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Common carotid artery intima-media thickness increases throughout the pregnancy cycle: a prospective cohort study.

ABSTRACT: BACKGROUND:High parity is associated with greater cardiovascular disease (CVD) among mid-life and older women. Prospective studies of arterial change throughout pregnancy are needed to provide insight into potential mechanisms. This study assessed vascular adaptation across pregnancy in healthy first-time pregnant women. METHODS:The Maternal Vascular Adaptation to Healthy Pregnancy Study (Pittsburgh, PA, 2010-2015) assessed 37 primigravid women each trimester, 6-8 weeks after delivery and 1-5 years postpartum, with B-mode ultrasound imaging of common carotid artery (CCA) intima-media thickness (IMT) and inter-adventitial diameter (IAD) to assess associations with physical and cardiometabolic measures. RESULTS:Thirty-seven women (age 28.2?±?4.5 years, pre-pregnant BMI 24.4?±?3.2 kg/m2) experienced uncomplicated pregnancies. After adjustment for age and pre-pregnancy BMI, mean (SE) IAD (mm) increased each trimester, from 6.38 (0.08) in the 1st trimester to 6.92 (0.09) in the 3rd trimester, and then returned to 1st trimester levels postpartum (6.35 [0.07], P?

SUBMITTER: Niemczyk NA 

PROVIDER: S-EPMC5984334 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Common carotid artery intima-media thickness increases throughout the pregnancy cycle: a prospective cohort study.

Niemczyk Nancy Anderson NA   Bertolet Marianne M   Catov Janet M JM   Desai Mansi M   McClure Candace K CK   Roberts James M JM   Sekikawa Akira A   Tepper Ping Guo PG   Barinas-Mitchell Emma J EJ  

BMC pregnancy and childbirth 20180531 1

<h4>Background</h4>High parity is associated with greater cardiovascular disease (CVD) among mid-life and older women. Prospective studies of arterial change throughout pregnancy are needed to provide insight into potential mechanisms. This study assessed vascular adaptation across pregnancy in healthy first-time pregnant women.<h4>Methods</h4>The Maternal Vascular Adaptation to Healthy Pregnancy Study (Pittsburgh, PA, 2010-2015) assessed 37 primigravid women each trimester, 6-8 weeks after deli  ...[more]

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