Ontology highlight
ABSTRACT:
SUBMITTER: Cross BM
PROVIDER: S-EPMC3948975 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Cross Brandie M BM Breitwieser Gerda E GE Reinhardt Timothy A TA Rao Rajini R
American journal of physiology. Cell physiology 20131113 6
Breast cancer is the second leading cause of cancer mortality in women, estimated at nearly 40,000 deaths and more than 230,000 new cases diagnosed in the U.S. this year alone. One of the defining characteristics of breast cancer is the radiographic presence of microcalcifications. These palpable mineral precipitates are commonly found in the breast after formation of a tumor. Since free Ca(2+) plays a crucial role as a second messenger inside cells, we hypothesize that these chelated precipitat ...[more]