Ontology highlight
ABSTRACT:
SUBMITTER: Wolters M
PROVIDER: S-EPMC3949328 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Wolters Manuel M Boyle Erin C EC Lardong Kerstin K Trülzsch Konrad K Steffen Anika A Rottner Klemens K Ruckdeschel Klaus K Aepfelbacher Martin M
The Journal of biological chemistry 20130626 32
Pathogenic Yersinia spp. translocate the effectors YopT, YopE, and YopO/YpkA into target cells to inactivate Rho family GTP-binding proteins and block immune responses. Some Yersinia spp. also secrete the Rho protein activator cytotoxic necrotizing factor-Y (CNF-Y), but it has been unclear how the bacteria may benefit from Rho protein activation. We show here that CNF-Y increases Yop translocation in Yersinia enterocolitica-infected cells up to 5-fold. CNF-Y strongly activated RhoA and also dela ...[more]