Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC3949332 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Li Jing J Zhang Yujing Y Liu Yuchen Y Dai Xin X Li Wenyang W Cai Xing X Yin Yuan Y Wang Qiang Q Xue Yunxing Y Wang Cheng C Li Dameng D Hou Dongxia D Jiang Xiaohong X Zhang Junfeng J Zen Ke K Chen Xi X Zhang Chen-Yu CY
The Journal of biological chemistry 20130613 32
Recent studies by our group and others show that microRNAs can be actively secreted into the extracellular environment through microvesicles (MVs) and function as secretory signaling molecules that influence the recipient cell phenotypes. Here we investigate the role of monocyte-secreted miR-150 in promoting the capillary tube formation of endothelial cells and in enhancing angiogenesis. In vitro capillary tube formation and in vivo angiogenesis assays showed that monocyte-derived MVs have stron ...[more]