Ontology highlight
ABSTRACT:
SUBMITTER: Lee JH
PROVIDER: S-EPMC3951122 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Lee Joo-Hyeon JH Bhang Dong Ha DH Beede Alexander A Huang Tian Lian TL Stripp Barry R BR Bloch Kenneth D KD Wagers Amy J AJ Tseng Yu-Hua YH Ryeom Sandra S Kim Carla F CF
Cell 20140101 3
Lung stem cells are instructed to produce lineage-specific progeny through unknown factors in their microenvironment. We used clonal 3D cocultures of endothelial cells and distal lung stem cells, bronchioalveolar stem cells (BASCs), to probe the instructive mechanisms. Single BASCs had bronchiolar and alveolar differentiation potential in lung endothelial cell cocultures. Gain- and loss-of-function experiments showed that BMP4-Bmpr1a signaling triggers calcineurin/NFATc1-dependent expression of ...[more]