Ontology highlight
ABSTRACT:
SUBMITTER: Kwon Y
PROVIDER: S-EPMC3951131 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Kwon Young Y Vinayagam Arunachalam A Sun Xiaoyun X Dephoure Noah N Gygi Steven P SP Hong Pengyu P Perrimon Norbert N
Science (New York, N.Y.) 20131010 6159
The Hippo pathway controls metazoan organ growth by regulating cell proliferation and apoptosis. Many components have been identified, but our knowledge of the composition and structure of this pathway is still incomplete. Using existing pathway components as baits, we generated by mass spectrometry a high-confidence Drosophila Hippo protein-protein interaction network (Hippo-PPIN) consisting of 153 proteins and 204 interactions. Depletion of 67% of the proteins by RNA interference regulated the ...[more]