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Synthesis of C11-Desmethoxy Soraphen A: A natural product analog that inhibits acetyl-CoA carboxylase.


ABSTRACT: A synthesis of C11-desmethoxy soraphen A is described that proceeds in just 14 steps from readily available starting materials. This natural product analog was identified as a target of interest in a program aimed at identifying novel natural product-inspired inhibitors of acetyl-CoA carboxylase (ACC) as potential anticancer therapeutics. While describing the most efficient synthesis of a soraphen A analog (total syntheses of the natural product have been reported that proceed in 25 to ≥40 linear steps), we also present data supporting the conclusion that C11-heteroatom functionality is a beneficial but unnecessary structural characteristic of soraphen A analogs for inhibiting ACC.

SUBMITTER: Canterbury DP 

PROVIDER: S-EPMC3951358 | biostudies-literature |

REPOSITORIES: biostudies-literature

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