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Regulatory T cells prevent liver fibrosis during HIV type 1 infection in a humanized mouse model.

ABSTRACT: Human immunodeficiency virus type 1 (HIV-1) disease is associated with aberrant immune activation, and coinfection with hepatitis C virus (HCV) exacerbates hepatic inflammation and fibrosis. However, the role of HIV-1 infection or host immune modulation in liver pathogenesis is not clearly defined. Here, we report that regulatory T (Treg) cells prevent liver immunopathogenesis during HIV-1 infection in a humanized mouse model. In the absence of Treg cells, HIV-1 infection induced liver fibrosis associated with hepatic stellate cell activation, hepatitis, and liver injury. Our findings provide new insight linking Treg cells and liver immunopathogenesis during HIV-1 infection.

SUBMITTER: Nunoya J

PROVIDER: S-EPMC3952666 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Regulatory T cells prevent liver fibrosis during HIV type 1 infection in a humanized mouse model.

Nunoya Jun-Ichi J Washburn Michael L ML Kovalev Grigoriy I GI Su Lishan L

The Journal of infectious diseases 20131016 7

Human immunodeficiency virus type 1 (HIV-1) disease is associated with aberrant immune activation, and coinfection with hepatitis C virus (HCV) exacerbates hepatic inflammation and fibrosis. However, the role of HIV-1 infection or host immune modulation in liver pathogenesis is not clearly defined. Here, we report that regulatory T (Treg) cells prevent liver immunopathogenesis during HIV-1 infection in a humanized mouse model. In the absence of Treg cells, HIV-1 infection induced liver fibrosis ...[more]

PMID: 24133182

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