Ontology highlight
ABSTRACT:
SUBMITTER: Wills MK
PROVIDER: S-EPMC3952845 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Wills Melanie K B MK Tong Jiefei J Tremblay Sylvie L SL Moran Michael F MF Jones Nina N
Molecular biology of the cell 20140115 6
Proto-oncogenic Src homology and collagen (Shc) proteins have been considered archetypal adaptors of epidermal growth factor receptor (EGFR)-mediated signaling. We report that in addition to its role as an EGFR-binding partner and Grb2 platform, ShcD acts noncanonically to promote phosphorylation of select EGFR residues. Unexpectedly, Y1068, Y1148, and Y1173 are subject to ShcD-induced, cell-autonomous hyperphosphorylation in the absence of external stimuli. This response is not elicited by othe ...[more]