Ontology highlight
ABSTRACT:
SUBMITTER: Ghasemzadeh M
PROVIDER: S-EPMC3953078 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Ghasemzadeh Mehran M Kaplan Zane S ZS Alwis Imala I Schoenwaelder Simone M SM Ashworth Katrina J KJ Westein Erik E Hosseini Ehteramolsadat E Salem Hatem H HH Slattery Robyn R McColl Shaun R SR Hickey Michael J MJ Ruggeri Zaverio M ZM Yuan Yuping Y Jackson Shaun P SP
Blood 20130402 22
Thrombosis promotes leukocyte infiltration into inflamed tissues, leading to organ injury in a broad range of diseases; however, the mechanisms by which thrombi guide leukocytes to sites of vascular injury remain ill-defined. Using mouse models of endothelial injury (traumatic or ischemia reperfusion), we demonstrate a distinct process of leukocyte recruitment, termed "directed intravascular migration," specifically mediated by platelet thrombi. Single adherent platelets and platelet aggregates ...[more]