Ontology highlight
ABSTRACT:
SUBMITTER: Jager J
PROVIDER: S-EPMC3953693 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Jäger Julia J Greiner Vera V Strzoda Daniela D Seibert Oksana O Niopek Katharina K Sijmonsma Tjeerd P TP Schäfer Michaela M Jones Allan A De Guia Roldan R Martignoni Marc M Dallinga-Thie Geesje M GM Diaz Mauricio B MB Hofmann Thomas G TG Herzig Stephan S
Molecular metabolism 20140108 2
Disturbances in lipid homeostasis are hallmarks of severe metabolic disorders and their long-term complications, including obesity, diabetes, and atherosclerosis. Whereas elevation of triglyceride (TG)-rich very-low-density lipoproteins (VLDL) has been identified as a risk factor for cardiovascular complications, high-density lipoprotein (HDL)-associated cholesterol confers atheroprotection under obese and/or diabetic conditions. Here we show that hepatocyte-specific deficiency of transcription ...[more]