Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism

ABSTRACT: Accumulation of excess nutrients hampers proper liver function and is linked to non-alcoholic fatty liver disease (NAFLD) in obesity. However, the signals responsible for an impaired adaptation of hepatocytes to obesogenic dietary cues remain still largely unknown. Post-translational modification by the Small Ubiquitin-like Modifier (SUMO), allows for a dynamic regulation of numerous processes including transcriptional reprogramming. We demonstrate that specific SUMOylation of transcription factor Prox1 represents a nutrient-sensitive determinant of hepatic fasting metabolism. Prox1 is highly SUMOylated on lysine 556 in the liver of ad libitum and re-fed mice, while this modification is abolished upon fasting. In the context of diet-induced obesity, Prox1 SUMOylation becomes less sensiti

SUBMITTER: Dr. Ana Jimena Alfaro 

PROVIDER: S-SCDT-10_15252-EMBR_202255981 | biostudies-other |

REPOSITORIES: biostudies-other