Ontology highlight
ABSTRACT:
SUBMITTER: Zheng X
PROVIDER: S-EPMC3953951 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Zheng Xingguo X Valakh Vera V Diantonio Aaron A Ben-Shahar Yehuda Y
eLife 20140101
Neurons regulate ionic fluxes across their plasma membrane to maintain their excitable properties under varying environmental conditions. However, the mechanisms that regulate ion channels abundance remain poorly understood. Here we show that pickpocket 29 (ppk29), a gene that encodes a Drosophila degenerin/epithelial sodium channel (DEG/ENaC), regulates neuronal excitability via a protein-independent mechanism. We demonstrate that the mRNA 3'UTR of ppk29 affects neuronal firing rates and associ ...[more]