Ontology highlight
ABSTRACT:
SUBMITTER: Price NE
PROVIDER: S-EPMC3954461 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Price Nathan E NE Johnson Kevin M KM Wang Jin J Fekry Mostafa I MI Wang Yinsheng Y Gates Kent S KS
Journal of the American Chemical Society 20140220 9
The loss of a coding nucleobase from the structure of DNA is a common event that generates an abasic (Ap) site (1). Ap sites exist as an equilibrating mixture of a cyclic hemiacetal and a ring-opened aldehyde. Aldehydes are electrophilic functional groups that can form covalent adducts with nucleophilic sites in DNA. Thus, Ap sites present a potentially reactive aldehyde as part of the internal structure of DNA. Here we report evidence that the aldehyde group of Ap sites in duplex DNA can form a ...[more]