Ontology highlight
ABSTRACT:
SUBMITTER: Guan L
PROVIDER: S-EPMC2784881 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20091001 42
The oxidized abasic lesion 5'-(2-phosphoryl-1,4-dioxobutane) (DOB) is produced concomitantly with a single-strand break by a variety of DNA-damaging agents that abstract a hydrogen atom from the C5'-position. Independent generation of the DOB lesion in DNA reveals that it reversibly forms interstrand cross-links (ICLs) selectively with a dA opposite the 3'-adjacent nucleotide. Product studies and the use of monoaldehyde models suggest that ICL formation involves condensation of the dialdehyde wi ...[more]