Ontology highlight
ABSTRACT:
SUBMITTER: Botham RC
PROVIDER: S-EPMC3954530 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20140116 4
Combination anticancer therapy typically consists of drugs that target different biochemical pathways or those that act on different targets in the same pathway. Here we demonstrate a new concept in combination therapy, that of enzyme activation with two compounds that hit the same biological target, but through different mechanisms. Combinations of procaspase-3 activators PAC-1 and 1541B show considerable synergy in activating procaspase-3 in vitro, stimulate rapid and dramatic maturation of pr ...[more]