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A Crowdsourced nucleus: understanding nuclear organization in terms of dynamically networked protein function.

ABSTRACT: The spatial organization of the nucleus results in a compartmentalized structure that affects all aspects of nuclear function. This compartmentalization involves genome organization as well as the formation of nuclear bodies and plays a role in many functions, including gene regulation, genome stability, replication, and RNA processing. Here we review the recent findings associated with the spatial organization of the nucleus and reveal that a common theme for nuclear proteins is their ability to participate in a variety of functions and pathways. We consider this multiplicity of function in terms of Crowdsourcing, a recent phenomenon in the world of information technology, and suggest that this model provides a novel way to synthesize the many intersections between nuclear organization and function. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development.

SUBMITTER: Wood AM

PROVIDER: S-EPMC3954575 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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A Crowdsourced nucleus: understanding nuclear organization in terms of dynamically networked protein function.

Wood Ashley M AM Garza-Gongora Arturo G AG Kosak Steven T ST

Biochimica et biophysica acta 20140109 3

The spatial organization of the nucleus results in a compartmentalized structure that affects all aspects of nuclear function. This compartmentalization involves genome organization as well as the formation of nuclear bodies and plays a role in many functions, including gene regulation, genome stability, replication, and RNA processing. Here we review the recent findings associated with the spatial organization of the nucleus and reveal that a common theme for nuclear proteins is their ability t ...[more]

PMID: 24412853

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