Lamin post-translational modifications: emerging toggles of nuclear organization and function.
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ABSTRACT:
SUBMITTER: Murray-Nerger LA
PROVIDER: S-EPMC8793286 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Lamin post-translational modifications: emerging toggles of nuclear organization and function.
Murray-Nerger Laura A LA Cristea Ileana M IM
Trends in biochemical sciences 20210618 10
Nuclear lamins are ancient type V intermediate filaments with diverse functions that include maintaining nuclear shape, mechanosignaling, tethering and stabilizing chromatin, regulating gene expression, and contributing to cell cycle progression. Despite these numerous roles, an outstanding question has been how lamins are regulated. Accumulating work indicates that a range of lamin post-translational modifications (PTMs) control their functions both in homeostatic cells and in disease states su ...[more]
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