Ontology highlight
ABSTRACT:
SUBMITTER: Qi CL
PROVIDER: S-EPMC3954694 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Qi Cui-Ling CL Wei Bo B Ye Jie J Yang Yang Y Li Bin B Zhang Qian-Qian QQ Li Jiang-Chao JC He Xiao-Dong XD Lan Tian T Wang Li-Jing LJ
PloS one 20140314 3
Studies have indicated that the aggregation of activated platelets with cancer cells facilitates tumor metastasis; the adhesion molecule P-selectin may be an important mediator of this process, but the detailed mechanism is unclear. In the current study, we established a B16F10 (B16) cell metastatic model in P-selectin knockout (P-sel-/-) mice to determine the effect of P-selectin-mediated platelet adhesion on metastasis. Compared with C57 mice, P-sel-/- mice developed fewer metastatic foci, and ...[more]