P-selectin-mediated platelet adhesion promotes tumor growth.
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ABSTRACT:
SUBMITTER: Qi C
PROVIDER: S-EPMC4466636 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
P-selectin-mediated platelet adhesion promotes tumor growth.
Qi Cuiling C Wei Bo B Zhou Weijie W Yang Yang Y Li Bin B Guo Simei S Li Jialin J Ye Jie J Li Jiangchao J Zhang Qianqian Q Lan Tian T He Xiaodong X Cao Liu L Zhou Jia J Geng Jianguo J Wang Lijing L
Oncotarget 20150301 9
Blood platelets foster carcinogenesis. We found that platelets are accumulated in human tumors. P-selectin deficiency and soluble P-selectin abolish platelet deposition within tumors, decreasing secretion of vascular endothelial growth factor and angiogenesis, thereby suppressing tumor growth. Binding of the P-selectin cytoplasmic tail to talin1 triggers the talin1 N-terminal head to interact with the β3 cytoplasmic tail. This activates αIIbβ3 and recruits platelets into tumors. Platelet infiltr ...[more]
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