Ontology highlight
ABSTRACT:
SUBMITTER: Shlevkov E
PROVIDER: S-EPMC6937139 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Shlevkov Evgeny E Basu Himanish H Bray Mark-Anthony MA Sun Zheng Z Wei Wei W Apaydin Kaan K Karhohs Kyle K Chen Pin-Fang PF Smith Janell L M JLM Wiskow Ole O Roet Kasper K Huang Xuan X Eggan Kevin K Carpenter Anne E AE Kleiman Robin J RJ Schwarz Thomas L TL
Cell reports 20190901 12
Dysregulated axonal trafficking of mitochondria is linked to neurodegenerative disorders. We report a high-content screen for small-molecule regulators of the axonal transport of mitochondria. Six compounds enhanced mitochondrial transport in the sub-micromolar range, acting via three cellular targets: F-actin, Tripeptidyl peptidase 1 (TPP1), or Aurora Kinase B (AurKB). Pharmacological inhibition or small hairpin RNA (shRNA) knockdown of each target promotes mitochondrial axonal transport in rat ...[more]