Ontology highlight
ABSTRACT:
SUBMITTER: Ahmari SE
PROVIDER: S-EPMC3954809 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Ahmari Susanne E SE Spellman Timothy T Douglass Neria L NL Kheirbek Mazen A MA Simpson H Blair HB Deisseroth Karl K Gordon Joshua A JA Hen René R
Science (New York, N.Y.) 20130601 6137
Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)-ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated hyperactivation over multiple days generated a progressive increase in grooming, a mouse behavior related to OCD. Incre ...[more]