Ontology highlight
ABSTRACT:
SUBMITTER: Davidson MG
PROVIDER: S-EPMC3954848 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Davidson Matthew G MG Alonso Michael N MN Yuan Robert R Axtell Robert C RC Kenkel Justin A JA Suhoski Megan M MM González Joseph C JC Steinman Lawrence L Engleman Edgar G EG
Journal of immunology (Baltimore, Md. : 1950) 20130621 3
In chronically inflamed tissues, such as those affected by autoimmune disease, activated Th cells often colocalize with monocytes. We investigate in this study how murine Th cells influence the phenotype and function of monocytes. The data demonstrate that Th1, Th2, and Th17 subsets promote the differentiation of autologous monocytes into MHC class II(+), CD11b(+), CD11c(+) DC that we call DCTh. Although all Th subsets induce the formation of DCTh, activated Th17 cells uniquely promote the forma ...[more]