Ontology highlight
ABSTRACT:
SUBMITTER: Parsa R
PROVIDER: S-EPMC5053226 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Parsa Roham R Lund Harald H Tosevski Ivana I Zhang Xing-Mei XM Malipiero Ursula U Beckervordersandforth Jan J Merkler Doron D Prinz Marco M Gyllenberg Alexandra A James Tojo T Warnecke Andreas A Hillert Jan J Alfredsson Lars L Kockum Ingrid I Olsson Tomas T Fontana Adriano A Suter Tobias T Harris Robert A RA
Glia 20160801 11
Intracerebral levels of Transforming Growth Factor beta (TGFβ) rise rapidly during the onset of experimental autoimmune encephalomyelitis (EAE), a mouse model of Multiple Sclerosis (MS). We addressed the role of TGFβ responsiveness in EAE by targeting the TGFβ receptor in myeloid cells, determining that Tgfbr2 was specifically targeted in monocyte-derived dendritic cells (moDCs) but not in CNS resident microglia by using bone-marrow chimeric mice. TGFβ responsiveness in moDCs was necessary for t ...[more]