Ontology highlight
ABSTRACT:
SUBMITTER: Slichter CK
PROVIDER: S-EPMC3955096 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Slichter Chloe K CK Friedrich David P DP Smith Rebecca J RJ Walsh Paula N PN Mize Greg G Czartoski Julie L JL McElrath M Juliana MJ Frahm Nicole N
Journal of immunological methods 20131225
HIV replication is unrestrained in vivo in the vast majority of infected subjects, and the ability of some rare individuals to control this virus is poorly understood. Standard immunogenicity assays for detecting HIV-1-specific CD8(+) T-cell responses, such as IFN-γ ELISpot and intracellular cytokine staining, generally fail to correlate with in vivo inhibition of HIV replication. Several viral inhibition assays, which measure the effectiveness of CD8(+) T-cell responses in suppressing HIV repli ...[more]