Ontology highlight
ABSTRACT:
SUBMITTER: Romani B
PROVIDER: S-EPMC3955192 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Romani Bizhan B Cohen Eric A EA
Current opinion in virology 20121010 6
Myeloid cells display a differential permissivity to primate lentivirus infection that is related to their ability to encode the Vpx and to a lesser extent the Vpr accessory proteins. Vpr is encoded by all primate lentiviruses, including HIV-1 and HIV-2, while its paralog, Vpx, is unique to HIV-2 and a subset of simian lentiviruses. Both proteins usurp the CRL4A (DCAF1) E3 ligase to fulfil their functions. Vpx induces the degradation of SAMHD1, a nucleotide triphosphohydrolase that blocks lentiv ...[more]