Ontology highlight
ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC5743084 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Zhou Xiaohong X DeLucia Maria M Hao Caili C Hrecka Kasia K Monnie Christina C Skowronski Jacek J Ahn Jinwoo J
The Journal of biological chemistry 20171027 51
The viral protein R (Vpr) is an accessory virulence factor of HIV-1 that facilitates infection in immune cells. Cellular functions of Vpr are tied to its interaction with DCAF1, a substrate receptor component of the CRL4 E3 ubiquitin ligase. Recent proteomic approaches suggested that Vpr degrades helicase-like transcription factor (HLTF) DNA helicase in a proteasome-dependent manner by redirecting the CRL4-DCAF1 E3 ligase. However, the precise molecular mechanism of Vpr-dependent HLTF depletion ...[more]