Ontology highlight
ABSTRACT:
SUBMITTER: Haziak K
PROVIDER: S-EPMC3956420 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Haziak Karolina K Herman Andrzej Przemysław AP Tomaszewska-Zaremba Dorota D
Mediators of inflammation 20140211
The present study was designed to examine the effect of intracerebroventricular (icv) administration of antilipopolysaccharide (LPS) antibody and blockade of Toll-like receptor 4 (TLR4) during immune stress induced by intravenous (iv) LPS injection on the gonadotropin-releasing hormone/luteinizing hormone (GnRH/LH) secretion in anestrous ewes. Injection of anti-LPS antibody and TLR4 blockade significantly (P < 0.01) reduced the LPS dependent lowering amount of GnRH mRNA in the median eminence (M ...[more]