Dataset Information

Tear osmolarity and dry eye symptoms in diabetics.

ABSTRACT:

Purpose

To assess the relationship between tear osmolarity and dry eye symptoms in patients with diabetes.

Patients and methods

Fifty patients with diabetes were enrolled. Demographic information and past medical history were recorded. Symptoms were assessed using the ocular surface disease index (OSDI). Tear osmolarity of each eye was measured with the TearLab® Osmolarity System.

Results

The majority of the subjects were female (76%), African American (56%), and/or had a diagnosis of type 2 diabetes (82%). The mean ± standard deviation (SD) for age was 54.6±13.4, and maximum tear osmolarity was 304.6±12.7 mOsm/L. Men had higher osmolarity than women (mean ± standard error (SE) 311.8±4.0 mOsm/L versus 302.3±1.9 mOsm/L, P=0.02). Age, race, use of artificial tears, years of diabetes, and hemoglobin A1c did not have a statistically significant association with tear osmolarity. Longer duration of diabetes was associated with lower (less severe) OSDI scores (r=-0.35, P=0.01). Higher tear osmolarity was associated with lower (less severe) OSDI scores (r=-0.29, P=0.04).

Conclusion

Approximately half of the diabetic subjects in our study had elevated tear osmolarity, and half of our population also reported symptoms consistent with dry eye disease. However, the two were slightly inversely related in that those with higher osmolarity reported fewer symptoms. Subjects with a longer duration of diabetes also reported fewer dry eye symptoms. Therefore, health care providers should be aware that patients who are most likely to have ocular surface disease, including those with long-standing diabetes, may not experience symptoms and seek care in a timely manner.

SUBMITTER: Fuerst N

PROVIDER: S-EPMC3956735 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Tear osmolarity and dry eye symptoms in diabetics.

Fuerst Nicole N Langelier Nicole N Massaro-Giordano Mina M Pistilli Maxwell M Stasi Kalliopi K Burns Carrie C Cardillo Serena S Bunya Vatinee Y VY

Clinical ophthalmology (Auckland, N.Z.) 20140310

<h4>Purpose</h4>To assess the relationship between tear osmolarity and dry eye symptoms in patients with diabetes.<h4>Patients and methods</h4>Fifty patients with diabetes were enrolled. Demographic information and past medical history were recorded. Symptoms were assessed using the ocular surface disease index (OSDI). Tear osmolarity of each eye was measured with the TearLab® Osmolarity System.<h4>Results</h4>The majority of the subjects were female (76%), African American (56%), and/or had a d ...[more]

PMID: 24648714

Similar Datasets

Project description:ImportanceKnowledge about the variability of measurements using the TearLab Osmolarity System is necessary when evaluating the clinical utility of readings.ObjectiveTo examine the variability of tear osmolarity measured by the TearLab Osmolarity System in patients with Sjögren syndrome (SS), patients with blepharitis, and control participants.Design, setting, and participantsCross-sectional study at a tertiary care academic center from June 13, 2012, to March 21, 2013. Participants included 74 eyes of 37 patients from a volunteer sample (18 patients with SS, 11 patients with blepharitis, and 8 control participants) who were evaluated using the TearLab Osmolarity System, with 3 consecutive osmolarity measurements taken at 1-minute intervals in a session; 15 of these patients had the same measurements taken by the same examiner in 2 additional sessions on the same day (9 AM-10 AM, 12 PM-1 PM, or 3 PM-4 PM). Most patients with SS and patients with blepharitis were taking systemic or topical dry eye medications at the time of enrollment.Main outcomes and measuresMean osmolarity and its variability calculated from a linear mixed model for each disease group that accounts for the variations attributable to different patients, eyes, and sessions and measurement error specific to each disease group.ResultsMean tear osmolarity was 307 mOsm/L, 304 mOsm/L, and 301 mOsm/L in the SS, blepharitis, and control groups, respectively (P = .46). The error associated with repeated measurements within a session in the patients without dry eye (10.5 mOsm/L [95% CI, 9.0-12.4]) was significantly lower than in the patients with blepharitis (14.6 mOsm/L [95% CI, 12.5-17.5]; P = .006) and patients with SS (15.8 mOsm/L [95% CI, 14.2-17.8]; P < .001) but a difference in the error of repeated measurements between patients with blepharitis and patients with SS was not identified (P = .46).Conclusions and relevanceThere was increased variability attributable to error in repeated measurements in patients with SS and patients with blepharitis compared with control participants. The high variability of TearLab osmolarity readings in all groups makes the clinical interpretation of measurements unclear.

Dataset Information

Tear osmolarity and dry eye symptoms in diabetics.

Purpose

Patients and methods

Results

Conclusion

Publications

Tear osmolarity and dry eye symptoms in diabetics.

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