Ontology highlight
ABSTRACT:
SUBMITTER: Nakamachi T
PROVIDER: S-EPMC4931240 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Nakamachi Tomoya T Ohtaki Hirokazu H Seki Tamotsu T Yofu Sachiko S Kagami Nobuyuki N Hashimoto Hitoshi H Shintani Norihito N Baba Akemichi A Mark Laszlo L Lanekoff Ingela I Kiss Peter P Farkas Jozsef J Reglodi Dora D Shioda Seiji S
Nature communications 20160627
Dry eye syndrome is caused by a reduction in the volume or quality of tears. Here, we show that pituitary adenylate cyclase-activating polypeptide (PACAP)-null mice develop dry eye-like symptoms such as corneal keratinization and tear reduction. PACAP immunoreactivity is co-localized with a neuronal marker, and PACAP receptor (PAC1-R) immunoreactivity is observed in mouse infraorbital lacrimal gland acinar cells. PACAP eye drops stimulate tear secretion and increase cAMP and phosphorylated (p)-p ...[more]