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Green fluorescent diamidines as diagnostic probes for trypanosomes.

ABSTRACT: Light-emitting diode (LED) fluorescence microscopy offers potential benefits in the diagnosis of human African trypanosomiasis and in other aspects of diseases management, such as detection of drug-resistant strains. To advance such approaches, reliable and specific fluorescent markers to stain parasites in human fluids are needed. Here we describe a series of novel green fluorescent diamidines and their suitability as probes with which to stain trypanosomes.

SUBMITTER: Giordani F 

PROVIDER: S-EPMC3957857 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Green fluorescent diamidines as diagnostic probes for trypanosomes.

Giordani Federica F   Munde Manoj M   Wilson W David WD   Ismail Mohamed A MA   Kumar Arvind A   Boykin David W DW   Barrett Michael P MP  

Antimicrobial agents and chemotherapy 20131223 3

Light-emitting diode (LED) fluorescence microscopy offers potential benefits in the diagnosis of human African trypanosomiasis and in other aspects of diseases management, such as detection of drug-resistant strains. To advance such approaches, reliable and specific fluorescent markers to stain parasites in human fluids are needed. Here we describe a series of novel green fluorescent diamidines and their suitability as probes with which to stain trypanosomes. ...[more]

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