Ontology highlight
ABSTRACT:
SUBMITTER: Begley DW
PROVIDER: S-EPMC3957879 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Begley Darren W DW Fox David D Jenner Dominic D Juli Christina C Pierce Phillip G PG Abendroth Jan J Muruthi Muigai M Safford Kris K Anderson Vanessa V Atkins Kateri K Barnes Steve R SR Moen Spencer O SO Raymond Amy C AC Stacy Robin R Myler Peter J PJ Staker Bart L BL Harmer Nicholas J NJ Norville Isobel H IH Holzgrabe Ulrike U Sarkar-Tyson Mitali M Edwards Thomas E TE Lorimer Donald D DD
Antimicrobial agents and chemotherapy 20131223 3
Macrophage infectivity potentiators (Mips) are immunophilin proteins and essential virulence factors for a range of pathogenic organisms. We applied a structural biology approach to characterize a Mip from Burkholderia pseudomallei (BpML1), the causative agent of melioidosis. Crystal structure and nuclear magnetic resonance analyses of BpML1 in complex with known macrocyclics and other derivatives led to the identification of a key chemical scaffold. This scaffold possesses inhibitory potency fo ...[more]