Ontology highlight
ABSTRACT:
SUBMITTER: Heinzelmann G
PROVIDER: S-EPMC3958442 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Heinzelmann Germano G Kuyucak Serdar S
PloS one 20140318 3
Excitatory amino acid transporters (EAATs) are membrane proteins that enable sodium-coupled uptake of glutamate and other amino acids into neurons. Crystal structures of the archaeal homolog GltPh have been recently determined both in the inward- and outward-facing conformations. Here we construct homology models for the mammalian glutamate transporter EAAT3 in both conformations and perform molecular dynamics simulations to investigate its similarities and differences from GltPh. In particular, ...[more]