Ontology highlight
ABSTRACT:
SUBMITTER: Underhill SM
PROVIDER: S-EPMC4159050 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Underhill Suzanne M SM Wheeler David S DS Li Minghua M Watts Spencer D SD Ingram Susan L SL Amara Susan G SG
Neuron 20140701 2
Amphetamines modify the brain and alter behavior through mechanisms generally attributed to their ability to regulate extracellular dopamine concentrations. However, the actions of amphetamine are also linked to adaptations in glutamatergic signaling. We report here that when amphetamine enters dopamine neurons through the dopamine transporter, it stimulates endocytosis of an excitatory amino acid transporter, EAAT3, in dopamine neurons. Consistent with this decrease in surface EAAT3, amphetamin ...[more]