Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
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ABSTRACT:
SUBMITTER: Takemura N
PROVIDER: S-EPMC3959210 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
Takemura Naoki N Kawasaki Takumi T Kunisawa Jun J Sato Shintaro S Lamichhane Aayam A Kobiyama Kouji K Aoshi Taiki T Ito Junichi J Mizuguchi Kenji K Karuppuchamy Thangaraj T Matsunaga Kouta K Miyatake Shoichiro S Mori Nobuko N Tsujimura Tohru T Satoh Takashi T Kumagai Yutaro Y Kawai Taro T Standley Daron M DM Ishii Ken J KJ Kiyono Hiroshi H Akira Shizuo S Uematsu Satoshi S
Nature communications 20140318
High-dose ionizing radiation induces severe DNA damage in the epithelial stem cells in small intestinal crypts and causes gastrointestinal syndrome (GIS). Although the tumour suppressor p53 is a primary factor inducing death of crypt cells with DNA damage, its essential role in maintaining genome stability means inhibiting p53 to prevent GIS is not a viable strategy. Here we show that the innate immune receptor Toll-like receptor 3 (TLR3) is critical for the pathogenesis of GIS. Tlr3(-/-) mice s ...[more]
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