Ontology highlight
ABSTRACT:
SUBMITTER: Qin Y
PROVIDER: S-EPMC3959674 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Qin Yanwen Y Xue Ling L Jiang Pingping P Xu Meifen M He Yiqun Y Shi Suxue S Huang Yangyiyi Y He Jiqiang J Mo Jun Qin JQ Guan Min-Xin MX
Journal of the American Heart Association 20140127 1
<h4>Background</h4>Coronary heart disease is the leading cause of death worldwide. Mitochondrial genetic determinants for the development of this disorder remain less explored.<h4>Methods and results</h4>We performed a clinical and genetic evaluation and mutational screening of 22 mitochondrial tRNA genes in a cohort of 80 genetically unrelated Han Chinese subjects and 125 members of 4 families with coronary heart disease and 512 Chinese control subjects. This analysis identified 16 nucleotide c ...[more]