Ontology highlight
ABSTRACT:
SUBMITTER: Willardsen M
PROVIDER: S-EPMC3959783 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Willardsen Minde M Hutcheson David A DA Moore Kathryn B KB Vetter Monica L ML
Mechanisms of development 20131109
Fibroblast growth factor signaling plays a significant role in the developing eye, regulating both patterning and neurogenesis. Members of the Pea3/Etv4-subfamily of ETS-domain transcription factors (Etv1, Etv4, and Etv5) are transcriptional activators that are downstream targets of FGF/MAPK signaling, but whether they are required for eye development is unknown. We show that in the developing Xenopus laevis retina, etv1 is transiently expressed at the onset of retinal neurogenesis. We found tha ...[more]