Constitutive activation of ectodermal ?-catenin induces ectopic outgrowths at various positions in mouse embryo and affects abdominal ventral body wall closure.
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ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC3960177 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Constitutive activation of ectodermal β-catenin induces ectopic outgrowths at various positions in mouse embryo and affects abdominal ventral body wall closure.
Zhu Xuming X Huang Sixia S Zhang Lingling L Wu Yumei Y Chen Yingwei Y Tao Yixin Y Wang Yushu Y He Shigang S Shen Sanbing S Wu Ji J Li Baojie B Guo Xizhi X He Lin L Ma Gang G
PloS one 20140319 3
Vertebrate limbs originate from the lateral plate mesoderm (LPM) and the overlying ectoderm. While normal limb formation in defined regions has been well studied, the question of whether other positions retain limb-forming potential has not been fully investigated in mice. By ectopically activating β-catenin in the ectoderm with Msx2-cre, we observed that local tissue outgrowths were induced, which either progressed into limb-like structure within the inter-limb flank or formed extra tissues in ...[more]
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