Ontology highlight
ABSTRACT:
SUBMITTER: Goodwin J
PROVIDER: S-EPMC3960982 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
NMR in biomedicine 20140128 4
The in vivo quantification of extracellular pH (pHe ) in tumours may provide a useful biomarker for tumour cell metabolism. In this study, we assessed the viability of continuous-wave electron paramagnetic resonance (CW-EPR) spectroscopy with a pH-sensitive nitroxide for the measurement of extracellular tumour pH in a mouse model. CW-EPR spectroscopy (750 MHz) of C3H HeJ mice hind leg squamous cell tumour was performed after intravenous tail vein injection of pH-sensitive nitroxide (R-SG, 2-(4-( ...[more]