Ontology highlight
ABSTRACT:
SUBMITTER: Nakaoka R
PROVIDER: S-EPMC9979135 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Nakaoka Ririko R Kato Kazuhiro K Yamamoto Kumiko K Yasui Hironobu H Matsumoto Shingo S Kirilyuk Igor A IA Khramtsov Valery V VV Inanami Osamu O Hirata Hiroshi H
Analytical chemistry 20230201 8
Extracellular acidification indicates a metabolic shift in cancer cells and is, along with tissue hypoxia, a hallmark of tumor malignancy. Thus, non-invasive mapping of extracellular pH (pHe) is essential for researchers to understand the tumor microenvironment and to monitor tumor response to metabolism-targeting drugs. While electron paramagnetic resonance (EPR) has been successfully used to map pHe in mouse xenograft models, this method is not sensitive enough to map pHe with a moderate amoun ...[more]