Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation.
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ABSTRACT:
SUBMITTER: Grigorian A
PROVIDER: S-EPMC3960996 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation.
Grigorian Ani A Mkhikian Haik H Li Carey F CF Newton Barbara L BL Zhou Raymond W RW Demetriou Michael M
Seminars in immunopathology 20120411 3
Autoimmune diseases such as multiple sclerosis (MS) result from complex and poorly understood interactions of genetic and environmental factors. A central role for T cells in MS is supported by mouse models, association of the major histocompatibility complex region, and association of critical T cell growth regulator genes such as interleukin-2 receptor (IL-2RA) and interleukin-7 receptor (IL-7RA). Multiple environmental factors (vitamin D(3) deficiency and metabolism) converge with multiple ge ...[more]
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