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Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis.

ABSTRACT: Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for angiogenesis and are not able to induce a compensatory angiogenesis. This review article is focused on current knowledge on the mechanisms responsible for angiogenesis dysregulation in systemic sclerosis.

SUBMITTER: Cantatore FP

PROVIDER: S-EPMC5534276 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis.

Cantatore Francesco Paolo FP Maruotti Nicola N Corrado Addolorata A Ribatti Domenico D

BioMed research international 20170716

Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an efficient vascular recovery. Vascular injury is responsible for hypoxia and tissual ischemia which are the primary triggers for angiogenesis and are not able to induce a compensatory angiogenesis. This review article is focused on current knowledge on the mechanisms responsible for angiogenesis dysregulation in systemic sclerosi ...[more]

PMID: 28791304

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