Synthesis of cyclic, multivalent Arg-Gly-Asp using sequential thiol-ene/thiol-yne photoreactions.
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ABSTRACT:
SUBMITTER: Aimetti AA
PROVIDER: S-EPMC3961633 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
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Synthesis of cyclic, multivalent Arg-Gly-Asp using sequential thiol-ene/thiol-yne photoreactions.
Aimetti Alex A AA Feaver Kristen R KR Anseth Kristi S KS
Chemical communications (Cambridge, England) 20100615 31
A unique method has been developed for the formation of multivalent cyclic peptides. This procedure exploits on-resin peptide cyclization using a photoinitiated thiol-ene click reaction and subsequent clustering using thiol-yne photochemistry. Both reactions utilize the sulfhydryl group on natural cysteine amino acids to participate in the thiol-mediated reactions. ...[more]
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