Ontology highlight
ABSTRACT:
SUBMITTER: Pofahl M
PROVIDER: S-EPMC3962646 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Nucleic acid therapeutics 20140204 2
We report on a multifunctional nucleic acid, termed AptamiR, composed of an aptamer domain and an antimiR domain. This composition mediates cell specific delivery of antimiR molecules for silencing of endogenous micro RNA. The introduced multifunctional molecule preserves cell targeting, anti-proliferative and antimiR function in one 37-nucleotide nucleic acid molecule. It inhibits cancer cell growth and induces gene expression that is pathologically damped by an oncomir. These findings will hav ...[more]