Spherical Nucleic Acids for Topical Treatment of Hyperpigmentation.
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ABSTRACT:
SUBMITTER: Fang Y
PROVIDER: S-EPMC8313479 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Spherical Nucleic Acids for Topical Treatment of Hyperpigmentation.
Fang Yang Y Lu Xueguang X Wang Dali D Cai Jiansong J Wang Yuyan Y Chen Peiru P Ren Mengqi M Lu Hao H Union Jennifer J Zhang Lei L Sun Yehui Y Jia Fei F Kang Xi X Tan Xuyu X Zhang Ke K
Journal of the American Chemical Society 20210112 3
Oligonucleotide-based materials such as spherical nucleic acid (SNA) have been reported to exhibit improved penetration through the epidermis and the dermis of the skin upon topical application. Herein, we report a self-assembled, skin-depigmenting SNA structure, which is based upon a bifunctional oligonucleotide amphiphile containing an antisense oligonucleotide and a tyrosinase inhibitor prodrug. The two components work synergistically to increase oligonucleotide cellular uptake, enhance drug ...[more]
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