Ontology highlight
ABSTRACT:
SUBMITTER: Phelps DL
PROVIDER: S-EPMC3962781 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Phelps Dale L DL Ward Robert M RM Williams Rick L RL Watterberg Kristi L KL Laptook Abbot R AR Wrage Lisa A LA Nolen Tracy L TL Fennell Timothy R TR Ehrenkranz Richard A RA Poindexter Brenda B BB Michael Cotten C C Hallman Mikko K MK Frantz Ivan D ID Faix Roger G RG Zaterka-Baxter Kristin M KM Das Abhik A Bethany Ball M M Michael O'Shea T T Backstrom Lacy Conra C Walsh Michele C MC Shankaran Seetha S Sánchez Pablo J PJ Bell Edward F EF Higgins Rosemary D RD
Pediatric research 20130904 6
<h4>Background</h4>Myo-inositol given to preterm infants with respiratory distress has reduced death, increased survival without bronchopulmonary dysplasia, and reduced severe retinopathy of prematurity in two randomized trials. Pharmacokinetic (PK) studies in extremely preterm infants are needed before efficacy trials.<h4>Methods</h4>Infants born in 23-29 wk of gestation were randomized to a single intravenous (i.v.) dose of inositol at 60 or 120 mg/kg or placebo. Over 96 h, serum levels (spars ...[more]