Ontology highlight
ABSTRACT:
SUBMITTER: Smith PB
PROVIDER: S-EPMC6535522 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20190524 6
Rifampin is active against methicillin-resistant staphylococcal species and tuberculosis (TB). We performed a multicenter, prospective pharmacokinetic (PK) and safety study of intravenous rifampin in infants of <121 days postnatal age (PNA). We enrolled 27 infants; the median (range) gestational age was 26 weeks (23 to 41 weeks), and the median PNA was 10 days (0 to 84 days). We collected 102 plasma PK samples from 22 of the infants and analyzed safety data from all 27 infants. We analyzed the d ...[more]