Ontology highlight
ABSTRACT:
SUBMITTER: De S
PROVIDER: S-EPMC3963273 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20110703 8
An unstable genome is a hallmark of many cancers. It is unclear, however, whether some mutagenic features driving somatic alterations in cancer are encoded in the genome sequence and whether they can operate in a tissue-specific manner. We performed a genome-wide analysis of 663,446 DNA breakpoints associated with somatic copy-number alterations (SCNAs) from 2,792 cancer samples classified into 26 cancer types. Many SCNA breakpoints are spatially clustered in cancer genomes. We observed a signif ...[more]